Danish Idrees, PhD

Danish Idrees is currently working as a Postdoctoral Research Scholar, University of Iowa, Iowa, USA at the Department of Nephrology, Division of Internal Medicine University of Iowa, Iowa, USA. I am currently pursuing a Post-doc in Nephrology with research primarily focused on ion channel physiology to the understanding of kidney diseases. My areas of interest include Structural biology, Biophysics, Molecular biology, Computational drug discovery and Structural bioinformatics. As part of my ongoing research, I am working on a project titled "Structural Insights into Polycytin-1/Polycystin-2 Complex Activation by the N-Terminal fragment of Polycytin-1", which aims to elucidate the molecular mechanisms underlying polycystin complex activation. By investigating the structural and biochemical interactions between PC-1 and PC-2, particularly the role of the PC-1 N-terminal fragment, research could provide valuable insights into their function in renal physiology and disease, such as autosomal dominant polycystic kidney disease (ADPKD). This understanding may pave the way for novel therapeutic strategies targeting polycystin-mediated signaling pathways. Danish Idrees has been awarded UGC-MANF in support of their academic and research pursuits. I have contributed to scientific literature with several publications.

1. SARS-CoV-2 spike protein interactions with amyloidogenic proteins: Potential clues to neurodegeneration, Biochemical and Biophysical Research Communications, Danish Idrees, Vijay Kumar, Volume 554, 21 May 2021, Pages 94-98.

2. Insight into the Conformational Transitions of Serine Acetyl Transferase Isoforms in E. histolytica: Implications for Structural and Functional Balance, Danish Idrees, Ahmad Abu Turab Naqvi, Md Imtaiyaz Hassan, Faizan Ahmad, Samudrala Gourinath, ACS Omega 2022, 7, 28, 24626–24637.

3. Delineating the effect of mutations on the conformational dynamics of N-terminal domain of TDP-43, Vijay Kumar, Preeti Pandey, Danish Idrees, Amresh Prakash, Andrew.M. Lynn, Biophysical Chemistry Biophysical Chemistry Volume 250, July 2019, 106174